Thiamax contains thiamine tetrahydrofurfuryl disulfide, a derivative of thiamine (vitamin B1) with high bioavailability. This form has been shown to cross the blood-brain-barrier and can bypass normal routes of thiamine absorption, with a higher rate of uptake both in the gut and at the cellular level.

Thiamax also includes a small amount of magnesium (as magnesium taurate), which plays an important role in supporting how cells can use thiamine.